Neuronale Zeroidlipofuszinose 12 (NCL-12) - Australian Cattle Dog Mischling The first symptoms of ventricular

The first symptoms of ventricular arrhythmia in affected dogs occur from 7 to 12 months of age and in some cases result in sudden death

that are commonly mistaken for epileptic seizures

retina and other tissues

Dog is homozygous for uniform coat coloration in pigmented areas

Mutation: NHEJ1 gene

Neuronale Zeroidlipofuszinose 12 (NCL-12) - Australian Cattle Dog Mischling The first symptoms of ventricularNeuronal ceroid lipofuscinosis is a lysosomal storage disease, characterized by neurodegeneration and decline in neurological functions at approximately 6 years of age due to accumulation of autofluorescent lysosomal storage bodies in cells of the central nervous system, as well as many other tissues. The clinical signs also include anxiety, impaired ability to recognize and respond to previously learned commands, increased sensitivity to loud or