Kupfertoxikose (CT) - Dobermann Labrador Retriever When mutated

When mutated

It is caused by axonal swelling in the cerebellum and abnormalities in the brain stem

I-Locus controls the intensity of the red pigment in dogs through affecting the expression of the pheomelanin pigment

schwere Erkrankung

Results are reported as combined results as well as results for each single allele tested

Kupfertoxikose (CT) - Dobermann Labrador Retriever When mutatedCopper metabolism disorders are genetic disorders of copper metabolism in the liver caused by mutations in two genes that code copper transporters ATP7A and ATP7B. The ATP7A transporter is crucial for copper transport from fibroblasts into the liver and the ATP7B is crucial for copper export from the liver. Mutations in the ATP7A result in defective ATP7A transporter so the copper cannot be properly exported from fibroblasts and imported into the