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In mammalian cells, HIF-1 can regulate the expression of cyt c oxidasecytochrome c oxidase subunit IV (COX4) by activating the transcription of genes encoding COX42 and LON to optimize the efficiency of respiration under hypoxic conditions [113]

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In long-term studies using fruit flies (Drosophila melanogaster) and rodent models, Epithalon administration was associated with statistically significant increases in mean and maximum lifespan

As a result, senescent cells could undergo programmed cell death

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