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PubMed laboratory research record [PMID: 42156721] PubMed record related to this compound for laboratory literature review

For silencing FOXO4, specific small interfering RNA (siRNA) was employed, with a negative control siRNA, and transfection was conducted using Lipofectamine 3000 [2]

PRMT5 inhibitors GSK591 and ly-283 caused a broad inhibition of transcriptome splicing in GBM cells, particularly affecting the products of cell cycle genes and prolonged survival in the PDX mouse model

These alterations may be further exacerbated by oxidative stress and activation of profibrotic cytokines, such as transforming growth factor , ultimately contributing to the development of chronic kidney disease (82)

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