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GLP-1RAs and clinical trials in NAFLD Lixisenatide In a systematic meta-analysis including 12 randomized controlled trials (RCTs) comparing lixisenatide to placebo or active interventions in T2D, lixisenatide was reported to normalize levels of alanine aminotransferase (ALT) in a greater proportion of overweight and obese patients with T2D than comparators (54)

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Semaglutide also enhances glucose-dependent insulin secretion from the pancreas

This has the secondary effect of increasing levels of the enzyme tyrosinase and melanocyte [2, 3]