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These conditions include aging and age-associated chronic muscle conditions such as cachexia 248 , sarcopenia 124,249,250 , inclusion body myositis (IBM) 114,251,252 , and neuromuscular diseases like Duchennes muscular dystrophy (DMD) 253,254

Unfortunately, these levels progressively diminish by 10% every decade

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Regulation of mitochondria-nucleus signaling Bidirectional communication between mitochondria and the nucleus is another promising target for therapeutic intervention