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Nevertheless, emerging data allow us to propose that severe hyperhomocysteinemia might primarily have homocysteinylation effects related to homocysteine and/or its by-products (as homocysteine thiolactone) that would affect the vascular wall structure through a mechanism independent of an oxidant stress

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Till date, eight different isozymes, viz., GPx1-GPx8, have been identified in humans, of which GPx1, GPx2, GPx3, GPx4, and GPx6 are selenoenzymes containing Sec in their active site (Table 1) [1, 8, 9]

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That framing tends to land better than a yearly lump-sum conversation