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31 These variants are additionally proposed to result in a more robust de novo thymidylate biosynthesis as a consequence of declining amounts of 5,10-methyleneTHF being available for irreversible reduction to 5-methylTHF via action of the MTHFR enzyme

A holistic approach, including a balanced diet, regular exercise, and lifestyle modifications, is essential for long-term weight management

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Excess weight is strongly linked to sleep problems such as sleep apnea, which can cause: Frequent awakenings Poor sleep quality Daytime fatigue As weight decreases, breathing improves, inflammation decreases, and sleep quality often improves significantly

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Comparative effectiveness of GLP-1 receptor agonists on glycaemic control and weight management: a systematic review and network meta-analysis