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There was a progressive decrease of the proportion of patients at target for each 0.5% increase in baseline HbA1c, ranging from 57.8% for HbA1c 7.5% to 20.8% for HbA1c 10% (p for trend 9.0% with no further decrease, whereas for non-insulin drugs the relationship was continuous without any evidence of plateau 5

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183 However, in vitro both of these mechanisms were not responsible for insulins drastic enhancement of cytotoxicity of the folic acid analog methotrexate to MCF-7 human breast cancer cells