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The goal of this trial was to see whether in patients with overweight and obesity, who dont have diabetes, if their risk of cardiovascular events could be reduced by treatment with semaglutide, explained Michael Lincoff, MD, cardiologist for Cleveland Clinic
The results of the FIGHT and LIVE trial in fact failed to demonstrate a protective effect of liraglutide in patients with both acute and chronic HF, respectively [121, 122]
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The practical solution: use a smaller reconstitution volume (1.0 mL) during the early titration phase so the total solution volume is smaller and you draw more per dose (relatively), or accept that you will waste some peptide during the titration stages
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Give each dose at least four to six weeks before judging effectiveness
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