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Animal model studies demonstrate a biphasic response curve where low micromolar concentrations (110 M) produce maximal NF-B inhibition, while concentrations above 50 M show diminishing returns and, in some tissue types, paradoxical pro-inflammatory signaling

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Hence, we tested whether blockade of zonulin overcomes the induction of epithelial permeability by FSN from mice induced for CIA

Wnt/-catenin signaling