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The bottom line on GLP-1 timelines The most important thing to know about the GLP-1 results timeline is that progress takes time

There are many people who are against these drugs because of how they contribute to the idea that we can and should all be thin, she says theres a fear that this will contribute to more eating disorders, and that people will never be able to accept their bodies, theyll always be told: Well, you could be thinner, just use this medicine. For now, what clinicians can do is what most of them are already doing: screening patients for a history of eating disorders before prescribing GLP-1s

The inter-organelle complex formed by endosomal GLP-1R, ER VAPB and SPHKAP triggers a pool of ERMCS-localised cAMP/PKA signalling via the formation of a PKA-RI biomolecular condensate which leads to changes in mitochondrial contact site and cristae organising system (MICOS) complex phosphorylation, mitochondrial remodelling, and -cell functional adaptation, with important consequences for the regulation of -cell insulin secretion and survival to stress

2.13 Recycling measurement by confocal microscopy INS-1 832/3-SNAP-GLP-1R cells on coverslips were treated with agonist (100 nM) or vehicle for 30 minutes in serum-free RPMI, followed by washing