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CBX3 expression was significantly increased in the Non-Response group (Fig

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GSTs were shown to catalyze the conjugation between various xenobiotics with electrophilic centers (Figure 1) and the nucleophilic GSH, thus tagging the xenobiotic for vacuolar sequestration (Martinoia et al., 1993)

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Upon ligand binding dimerization of receptors takes place which is triggered by phosphorylation of tyrosine residues located in the kinase domains

To induce intracellular GSH depletion, cells were incubated in Cys 2 -free medium or with BSO (1000 M) treatment or erastin (10 M) treatment