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These include altered autonomic nervous system signalling that affects salivary glands, reduced fluid intake from appetite suppression, and mild dehydration from dietary changes

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In contrast, almost half of included studies showed no statistically significant improvement in glycemic status [19, 20, 22,23,24, 26, 29, 31]

Of these, upregulations in phosphofructokinase and pyruvate kinase are of particular note, as these represent rate-limiting catalytic steps within the glycolytic pathway, which is a described result of GLP-1 receptor stimulation that ultimately results in augmented ATP production