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Avoiding Freeze-Thaw Cycles Repeated freezing and thawing of the reconstituted solution can cause aggregation or potency loss

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30,32 A retrospective matched case-control study of 324 patients who underwent ACL reconstruction with meniscus repair (PRP vs control age: 91.6 11.2 vs 92.4 10.6) showed no significant difference in IKDC scores nor in the timing of return to activity nor postoperative complications among the intraoperative PRP injection group and the control group after 2 years 33 In addition, Bailey et al

improved collagen organization and tensile strength (PMID: 21030672) Gastrointestinal: Protection against NSAID-induced ulcers, IBD models, fistula healing in preclinical studies (PMID: 31158953) Nerve: Enhanced sciatic nerve regeneration

doi: 10.1080/10590500903310047 22 CohnBALa MerrillMKrigbaumNYYehGParkJ-SZimmermannLet al