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Comparative dual- versus triple-agonist pharmacology, run alongside GLP-1 (Sema) (single) and GLP-2 (Triz) (dual) to dissect receptor-specific effects

Injection site reactions are more common with amylin analogs, and the dual-mechanism approach means managing two sets of potential adverse effects

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The glucagon-like peptide 1 (GLP-1) analogue, Exendin-4, decreases the rewarding value of food: a new role for mesolimbic GLP-1 receptors