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If baseline levels are intact but receptor efficiency has degraded

This review will outline the physiology and pharmacological potential of amylin and GLP-1, respectively, and focus on innovative peptide drug development leading to drugs acting on two or more distinct receptors, such as an amylin and GLP-1 peptide hybrid, potentially producing a more effective treatment strategy to combat the rapidly increasing global obesity

Adems, no existe evidencia slida de seguridad/beneficio para su uso rutinario en la diabetes tipo 1, y el uso fuera de indicacin puede aumentar el riesgo de efectos adversos (especialmente gastrointestinales) y de descontrol glucmico si el paciente reduce la insulina por su cuenta

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Sep 2022;22(3):235-243