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Randomized controlled trials (SURMOUNT trials) demonstrated average weight loss of 1522% over 68 weeks at maximum doses, with most loss concentrated in the first 6 months as appetite suppression peaks and lifestyle changes solidify

However, high dosages of the B vitamins could lead to the development of or worsen diverticulitis

Under-fueling is one of those foundational issues, and it's something I commonly see in my own practice

It causes debilitating leg cramps that stop patients suddenly in their tracks, and in late stages, serves up Charlie Horses that wake them out of a sound sleep

Kankuri E, Finckenberg P, Leinonen J, Tarkia M, Bjrk S, Purhonen J, et al