Among currently available agents, GLP-1 RAs - and tirzepatide in particular, based on the SURMOUNT-1 subgroup analysis - have the most substantial weight-loss evidence in this population, with efficacy appearing comparable to that observed in common obesity
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to reduce the risk of major adverse cardiovascular events (cardiovascular death, non-fatal myocardial infarction or non-fatal stroke) in adults with type 2 diabetes and established cardiovascular disease
The SELS rs34713741 polymorphism is associated with susceptibility to colorectal cancer and gastric cancer: a meta-analysis
Thus, we propose QMP engineering as a strategy to ensure a long plasma half-life and enhanced therapeutic efficacy of albumin fusion proteins despite C-terminal cleavage
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