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Week 2: If week 1 was tolerated well, increase to 50% of the target dose

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Fig 1b demonstrates that the plasma TG level was significantly higher in the patients (88.92 59.54 mg/dL) (IQR = 77.85, %CV = 66.96) than that in the healthy controls (58.33 15.79 mg/dL) (IQR = 24.75, %CV = 27.06)

I designed this schematic on BioRender to visualize what I think is happening to my patients

We show that hepatic sulfur amino acid (SAA) metabolism is under transcriptional control of HNF4

One way to increase cellular levels is by ingesting N-acetylcysteine (NAC) which is absorbed from the digestive tract and releases cysteine in the bloodstream