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The risk with topical use is relatively low since systemic absorption is limited
25,102 A meta-analysis reported that increased circulating TMAO levels were closely associated with an increased risk of all-cause mortality in patients with CKD
10.1016/j.cell.2012.11.001 92 JiangD.GuoY.NiuC.LongS.JiangY.WangZ.et al (2023)
& Braak, H
Its possible to measure B6 as part of blood tests and IMO it might be best to use this to decide whether or not you need a lot of B6, I'm not a huge fan of supplementing blindly something which is toxic in excess, unless theres a clear signal from a blood test that justifies it
"A phase I-II study of the histone deacetylase inhibitor valproic acid plus chemoimmunotherapy in patients with advanced melanoma"
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