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Any sort of GI problem (including hormone imbalances like thyroid problems) may limit absorption
Do You Need a Prescription for B12 Shots
Intrinsic factor binds to vitamin B12, so that you can absorb it into the blood
Vitamin B12 stays in the body for different amounts of time
This is because there are few vegan foods that contain B12 and also because the body finds it significantly more difficult to absorb B12 from the few vegan sources that have it
That can slow how the dose is used and is a known issue, particularly in women and larger patients where there is more tissue to pass through
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