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Moderate-certainty evidence demonstrated that GLP-1 agonists probably decreased the risk of four-point major adverse cardiovascular events (composite outcome including cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or need for hospitalization or coronary revascularization for unstable angina pectoris or heart failure) compared with placebo over a median 200 weeks of follow-up (risk ratio = 0.77

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