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This is particularly relevant for medications with narrow therapeutic windows, like warfarin, thyroid hormones, and oral contraceptives

The older version of the test method should be archived in case it needs to be referred to later

Reviews and safety studies have found only a few isolated reports of menstrual or reproductive changes, meaning that shifts in cycle length, bleeding, or PMS symptoms appear to be rare

If the medication freezes, throw it away, even if it thaws out later

Ehrmann DA, Liljenquist DR, Kasza K, Azziz R, Legro RS, Ghazzi MN et al (2006) Prevalence and predictors of the metabolic syndrome in women with polycystic ovary syndrome

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