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Unlike its parent compound (Melanotan II), PT-141 has been optimized to selectively bind to central melanocortin receptors (MC3R and MC4R) while minimizing affinity for the MC1R receptors associated with melanogenesis (pigmentation)

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While glutamate is typically abundant in the standard human diet, cysteine and glycine are frequently depleted, especially during times of chronic metabolic stress, severe viral infection, or the natural aging process