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"Bydureon BCise- exenatide injection, suspension, extended release"
Recent studies of isolated L-cells (95) and a L-cell derived cell line, GLUTag cells, have shown stimulation of GLP-1 secretion by glucose acting to inhibit K+ channels as in islet beta cells, by activation of the SGLT-1 transporter leading to depolarization (91), or activation of sweet taste receptors (T1R2 / T1R3) which activate Gq and PLC
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However, most mechanistic evidence derives from experimental and ex vivo studies, whereas human data remain largely associative
DARU J Pharm Sci
The OSDI questionnaire revealed a consistent, though non-significant, trend toward lower symptom burden in GLP-1 RA users
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