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Since pancreatic secretion is under vagal control, interruption of vagal efferent fibers induces malabsorption (Camilleri et al., 2003)

A subsequent trial using a complete meal (rather than sugar alone) confirmed 30-33% reductions in blood glucose and 31-38% reductions in insulin across three dose levels

Its approved for type 2 diabetes by the FDA, but some doctors may prescribe it off label for obesity

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Comparison of renal outcomes between sodium glucose co-transporter 2 inhibitors and glucagon-like peptide 1 receptor agonists