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Most of these patients had type 2 diabetes (90.5%) and obesity (75.2%)
Initially marketed as Geref by EMD Serono, it was FDA-approved as a stimulation test for GHD diagnosis in 1990 and for therapy in children with short stature in 1997 [11]
The dose levels tested included 1mg, 4mg, 8mg, and 12mg weekly
Furthermore, among those already with a SUD, GLP-1s appeared to lower hospitalizations, overdoses, and death, GLP-1 receptor agonists are not replacements for current medication treatments for AUDbut may soon become important additions
Note: the effects are mild to modest as compared to injectables & topical retinoids
The increased activity of pro-inflammatory transcription factors and NF-B has also been associated with decreased glutamate receptor activity (96)
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