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Their clinical trials (NCT04542161) conclusively demonstrated that ME/CFS patients suffer from a significant, localized deficit of glutathione in the cerebral cortex, directly correlating with the severity of their neuroinflammation and cognitive dysfunction
Found naturally in plants, animals, fungi, and certain types of bacteria, this powerful molecule is produced in high concentrations in most of the bodys cellscomparable to glucose and potassium levels (Pizzorno, 2014)
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Hydrophobic residues I344, L348, L353 of G i line on one side of 5 to form hydrophobic interactions with GHSR residues I145 3.54 , I235 5.61 , I239 5.65 , and L265 6.37 ( Fig
Cells, therefore, employ antioxidantsthe most abundant of which in the brain is glutathione (GSH)to neutralize ROS by serving as electron donors to limit cell damage(Dringen, 2000
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