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Therefore, the acidic residues of p53 TAD appear to have no significant impact on its interaction with the FOXO4 FHD, as these residues primarily contribute to DNA selectivity rather than binding to the FOXO4 FHD

Seek urgent medical attention if you experience: Persistent high blood glucose readings (above 15 mmol/L) Symptoms of hyperglycaemia that don't improve with treatment Unexplained weight loss or persistent fatigue Diabetic ketoacidosis (DKA) is uncommon in type 2 diabetes but can occur in certain situations, particularly if you have significant insulin deficiency, are taking SGLT2 inhibitors, or have a serious illness

N Engl J Med 2000

Vitamin E: Vitamin E is a fat-soluble antioxidant that protects the skin from UV damage, reduces inflammation, and promotes skin healing

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