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Phase Dual escalation 1 Weeks 13-16 Retatrutide 8 mg/week Cagrilintide 0.5 mg/week Notes GI effects often peak here

Malabsorption Issues- Certain medical conditions, such as pernicious anaemia or gastrointestinal disorders, can interfere with the bodys ability to absorb B12 from food

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doi: 10.1016/j.niox.2014.11.012 80 ZhangLYangGUntereinerAJuYWuLWangR

Glucose is used to drive glycolysis and subsequent energy production 34

PMID: 21593563 6 Park SA, Byeon G, Jhoo JH, Kim HC, Lim MN, Jang JW, Bae JB, Han JW, Kim TH, Kwak KP, Kim BJ, Kim SG, Kim JL, Moon SW, Park JH, Ryu SH, Youn JC, Lee DW, Lee SB, Lee JJ, Lee DY, Kim KW