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For each eligible study, two authors (MM and AN) independently extracted data, which was then reviewed by a third author (JV) using a piloted spreadsheet, in accordance with Cochrane Collaboration guidelines ( Where relevant data were missing, attempts were made to contact corresponding authors

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Hypoxia-inducible factor 1 (HIF-1) is a crucial transcription factor modulating the high energy requirements of immune cells to perform their effector functions in low-oxygen states (6770)

Pheomelanin: This is a reddish or yellowish pigment