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While conclusive human studies are limited, excessive or prolonged use of IGF-1 or IGF1-LR3 should be avoided to minimize potential oncogenic effects
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Pediatr Neurol 2003, 28: 24-27
This structural damage causes further mitochondrial failure and even more ROS leakage, creating a continuous "doom loop" of profound energy depletion, systemic inflammation, and the hallmark symptom of post-exertional malaise (PEM)
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