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doi: 10.1002/1099-1573(200008)14:5 3.0.CO;2-G 460 ThiviyaPGunawardenaNGamageAMadhujithTMerahO

Abbreviations 5-HT: 5-hydroxytryptamine ADCY8: Adenylate cyclase 8 AHR: Aryl hydrocarbon receptor AI: Artificial intelligence AKR1B1: Aldo-keto reductase family 1 member B AKR1C1: Aldo-keto reductase family 1 member C1 Akt: Protein kinase B Anosim: Analysis of similarities ANS: Autonomic nervous system ARG1: Arginase 1 ASPH: Aspartate beta-hydroxylase ATF4: Activating transcription factor 4 AUC: Area under the curve BBB: Blood-brain barrier Bcl-2: BCL2 apoptosis regulator BDNF: Brain-derived neurotrophic factor CD8: Cytotoxic T lymphocytes CDC6: Cell division cycle 6 CDKN1A: Cyclin dependent kinase inhibitor 1 A CK: 20-O--(d-glucopyranosyl)-20(S)-protopanaxadiol CNS: Central nervous system COL1A2: Collagen type I alpha 2 chain CRC: Colorectal cancer CREB: cAMP responsive element binding protein CRUK: Cancer Research UK CSF3: Colony stimulating factor 3 CSF: Cerebrospinal fluid CTLA4: Cytotoxic T-lymphocyte associated protein 4 CYP1B1: Cytochrome P450 family 1 subfamily B member 1 DDIT4: DNA damage inducible transcript 4 DEPP1: DEPP autophagy regulator 1 DUSP6: Dual specificity phosphatase 6 ECM: Extracellular matrix EGFR: Epidermal growth factor receptor EIF4A2: Eukaryotic translation initiation factor 4A2 ENS: Enteric nervous system EREG: Epiregulin ERK: Extracellular signal regulated kinase FAM114A1: Family with sequence similarity 114 member A1 FDA: Food and Drug Administration FDFT1: Farnesyl-diphosphate farnesyltransferase 1 FMT: Faecal microbiota transplantation FOSL1: FOS like 1, AP-1 transcription factor subunit FOXP3: Forkhead box P3 FXR: Farnesoid X receptor GABA: Gamma-aminobutyric acid GBA: Gut-brain axis GBM: Glioblastoma GH: Growth hormone GLUT1: Glucose transporter 1 GWAS: Genome-wide association studies H 2 O 2 : Hydrogen peroxide HDAC: Histone deacetylase HIF-1: Hypoxia inducible factor 1 HK2: Hexokinase 2 HNRNPM: Heterogeneous nuclear ribonucleoprotein M HPA: Hypothalamic pituitary adrenal IDH: Iso-citrate dehydrogenase (NADP(+)) IDO1: Indoleamine 2,3-dioxygenase 1 Ifi: Interferon alpha inducible protein Ifit: Interferon-induced protein with tetratricopeptide repeats Ifitm: Interferon induced transmembrane protein IFN-: Interferon gamma IGF-1: Insulin like growth factor 1 IGF: Insulin-like growth factor IL: Interleukin iNOS: Inducible nitric oxide synthase Isg: Interferon-stimulated genes JAK: Janus kinase KEGG: Kyoto Encyclopaedia of Genes and Genomes L1CAM: L1 cell adhesion molecule LASSO: Least absolute shrinkage and selection operator LDHA: Lactate dehydrogenase A LEfSe: Linear discriminant analysis effect size LPS: Lipopolysaccharide MAP2: Microtubule associated protein 2 MCL1: MCL1 apoptosis regulator MCM10: Minichromosome maintenance 10 replication initiation factor MCM: Minichromosome maintenance complex component CCND1: Cyclin D1 MEK: Mitogen-activated protein kinase kinase MGMT: O-6-methylguanine-DNA methyltransferase MMP: Matrix metallopeptidase mRMR: Minimum redundancy-maximum relevance mTOR: Mechanistic target of rapamycin kinase NGF: Nerve growth factor NMDA: N-methyl-D-aspartate NMDS: Non-metric multidimensional scaling NOG: NOD/Shi-SCID, IL-2Rnull NTRK: Neurotrophic tyrosine receptor kinase OTU: Operational taxonomic units P2RY12: Purinergic receptor P2Y12 PALM2AKAP2: Paralemmin 2 and A-kinase anchoring protein 2 fusion PCA: Principal component analysis PCoA: Principal coordinates analysis PD-1: Programmed cell death 1 PD-L1: Programmed cell death 1 ligand 1 PI3K: Phosphatidylinositol-4,5-bisphosphate 3-kinase PICRUSt: Phylogenetic Investigation of Communities by Reconstruction of Unobserved States PKC: Protein kinase C alpha PKM2: Pyruvate kinase M1/2 PLAU: Plasminogen activator, urokinase PNS: Peripheral nervous system PTEN: Phosphatase and tensin homolog RAS: Rat sarcoma ROS: Reactive oxygen species RTK: Receptor tyrosine kinase SCFA: Short-chain fatty acids SCN: Suprachiasmatic nucleus SH2B3: SH2B adaptor protein 3 STAT: Signal transducer and activator of transcription SVM-RFE: Recursive Feature Elimination with Support Vector Machines T c cell: Cytotoxic T cell T reg : Regulatory T cell TAMs: Tumour associated macrophages TCGA: The Cancer Genome Atlas TGF: Transforming growth factor beta TGR5: Takeda G-protein-coupled receptor 5 TLR: Toll-like receptor TMAO: Trimethylamine-N-oxide TME: Tumour microenvironment TNF: Tumor necrosis factor TP53: Tumor protein p53 UHRF1: Ubiquitin like with PHD and ring finger domains 1 VEGF: Vascular endothelial growth factor WHO: World Health Organisation WNT7B: Wnt family member 7B Wnt: Wingless-type MMTV integration site family WT: Wildtype [312] References Lynch SV, Pedersen O

Williams has signed on as a celebrity patient ambassador for Ro and stars in the brands new multi-year campaign launching Thursday (Aug

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