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Based on available data, resmetirom has a good safety and tolerability profile, with mild nausea and diarrhea occurring more often with the active drug than placebo [64]
The primary objective was to demonstrate superiority of semaglutide 7.2 mg against placebo on weight loss after 72 weeks with respect to the percentage change in body weight and the proportion of participants achieving weight loss of 5% or greater
Most users find that patient dose escalation over 4 to 6 weeks allows the body to adapt and minimizes nausea and digestive issues
Key history elements (most yield, fewest assumptions): Temporal relationship : symptom onset vs semaglutide initiation, dose escalation, peak GI symptoms (which cluster early in treatment), and weight change trajectory
Sleep, energy, muscle preservation, or cognitive clarity
Although all patients experienced weight loss after starting GLP-1 RAs, this 67% reduction in weight is insufficient to explain the 4050% decrease in desmopressin dosage
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