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The sequence is proline-rich, with three consecutive prolines followed by a fourth at position eight, and that conformationally constrained backbone is the usual structural explanation offered for the resistance
Rodent studies involving pharmacological manipulation of GLP-1R in the brain by intracerebroventricular (ICV) administration of agonists and antagonists demonstrate a role for brain GLP-1R signaling in the control of glucose metabolism
Diabetes Care 39:17021710
They are popular due to their ease of use and availability, though they pass through the digestive system
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