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The Tohoku Journal of Experimental Medicine , 230 (1), 1723

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A model-based curve should never become a reason to change dose timing, delay professional advice, or assume that a symptom has one cause

The problem, however, was that the molecules half-life was much too short to serve as a useful medicine

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Tirzepatide's established adverse effect profile includes gastrointestinal symptoms (nausea, vomiting, diarrhoea, constipation) in a substantial proportion of users, particularly during dose escalation