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Eligible studies included randomised controlled trials, cohort, and case-control studies assessing B12 supplementation efficacy via oral, sublingual, or IM administration routes
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In dietinduced obese mice, NNMTi treatment significantly reduced liver weight, liver volume, and hepatic triglyceride levels, alleviated hepatic steatosis and inflammatory infiltration, downregulated inflammatory factors (such as TNF and IL6) and lipogenic genes (such as FAS), and upregulated lipolytic genes (such as ATGL) in the liver
You can take Vitamin B12 injections with minimal to no downtime
FDA's 2024 review states the mechanism of action is still unknown, which limits how confidently any specific physiological effect can be predicted in humans
Clinical Safety Data Clinical research involving approximately 900 participants across six human studies provides substantial safety data
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