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Recent observations highlighted the critical association with intestinal flora, as confirmed by the finding that metformin decreased the relative abundance of Bacteroides fragilis while increasing Akkermansia muciniphila and Bifidobacterium bifidum

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Watanabe, S., Ajisaka, R., Masuoka, T., Yamanouchi, T., Saitou, T., Toyama, M., Takeyasu, N., Sakamoto, K., and Sugishita, Y

Interactions with common perioperative and orthopedic drugs NSAIDs, corticosteroids, and anesthetic agents are uncharacterized, which matters precisely because orthopedic patients are frequently on those medications

Mutagenesis (2004) 19(4):32530

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