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One possible explanation for this is the inability of BDNF in its free form to penetrate the blood-brain barrier (38, 39)

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Compare that with GLP-1-based obesity medications, where trials have shown double-digit percentage body weight loss

Abebe TB, Gebreyohannes EA, Tefera YG, Abegaz TM

SAN ANTONIO, July 1, 2025 (Newswire.com) - In This Article, You'll Discover: Understanding the science behind GLP-1 pathways and their role in natural metabolic support for sustainable weight management