The higher degree genes from PPI network interacted with the genes were obtained
Discussion The worldwide issue of population aging is becoming increasingly problematic as the global economy and medical care expand
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It plays integral roles in: Immune regulation Cancer suppression (anti-proliferative and pro-apoptotic signaling) Mitochondrial function and redox balance Hormonal feedback loops, including cortisol and estrogen/testosterone rhythms Aging diminishes melatonin output by up to 75%, leading to weaker circadian cues and downstream systemic dysfunction
273 Furthermore, a study using the anterior cruciate ligament transection (ACLT) rat model further confirmed that subcutaneous injection of liraglutide at 50 g/kg/day, whether for 3 weeks or 6 weeks, could reduce OARSI scores, highlighting the potential of liraglutide in treating joint degeneration
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