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No licensed medications for insomnia exist for children and adolescents in Canada, appropriate formulations are also lacking, and guidance regarding safety and appropriate treatment doses for different ages is limited

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The results of these studies support and confirm observations in-vivo indicating that intact DSIP crosses the BBB by simple transmembrane diffusion

Traditional oral forms may be poorly absorbed, as glutathione can be broken down by the digestive system before it reaches the bloodstream

Key issues identified 1 Impurity formation when mixed with additives