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Walker confirms they had an aspirational goal of creating a "gastric bypass in a pill." One key observation was that bypass surgery suppresses appetite partly by elevating multiple gut hormones -- GLP-1, CCK, and PYY all increase after the surgery

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There is no absolute contraindication to using these medications in hypothyroid patients, and clinical trials have included participants with thyroid disorders

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Ollero et al., 2011)

To do so, the DoD must be staffed with technically savvy personnel