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Testing was performed according to the up-down method described above
Another trial, SOUL (NCT03914326), has now been initiated to overcome the shortcomings of PIONEER 6 with a primary endpoint focused at proving CV superiority vs placebo
In the phase 2 clinical trial (Jastreboff et al., New England Journal of Medicine , 2023), retatrutide was administered as a once-weekly subcutaneous injection, with doses escalated gradually over time a regimen that reflects the trial protocol
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My follow-up X-ray at week six showed solid callus formation, and my doctor seemed surprised at how well things were progressing
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