However, individuals with rare genetic conditions like Lebers hereditary optic neuropathy or those with known severe hypersensitivities to cobalt should avoid these shots
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Testing MTHFR and other relevant genetic markers can identify these individuals, though routine genetic testing for b12 supplementation decisions remains controversial
Clinical trial dosing: what the research shows Understanding proven protocols provides the foundation
Community sources report a 16-week subcutaneous ladder of 250 mcg daily for Weeks 1-4, 375 mcg daily for Weeks 5-8, and 500 mcg daily for Weeks 9-16, but this is reported research context, not a recommendation
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