Initially launched in 2023 for obesity-related conditions, its potent weight loss effects (20-25% body weight reduction) make it a promising solution, given that excess weight is a leading risk factor for OSA in 75-80% of cases
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The FDA-approved semaglutide formulations include Ozempic (for type 2 diabetes) and Wegovy (for chronic weight management)
GLP-1 (glucagon-like peptide-1) receptor agonists are a class of medications that mimic the action of naturally occurring GLP-1, an incretin hormone produced in the intestinal L-cells following food intake
Now, Topiramate is labeled as a pregnancy category D drug, as new data shows risks for development of cleft lip, cleft palate and oral clefts generally
Big Pharma is squarely focused on GLP-1 medications right now