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A widely cited study by Kraus and colleagues used genetic knockdown in mice

The speed at which B12 treats nerve symptoms shows differences between patients

Safety and Precautions Before receiving B12 injections, inform your provider about: All medications and supplements you take Any known allergies Your medical history Individuals with certain rare conditions (such as Lebers disease) or sensitivities to specific forms of B12 may need alternative approaches

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The absence of safety data in these populations means that use should be avoided or approached with extreme caution and specialized medical supervision

Deltoid (upper arm) if someone else administers