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[15] Epimerases (EC 5.1), a subclass of isomerases, catalyze configurational changes at a single asymmetric carbon atom, typically via a deprotonation/protonation mechanism

This might happen if: Weight loss progress slows down Side effects are difficult to tolerate Blood sugar levels require better management Another medication may be better suited to the patients metabolism Instead of combining medications, providers typically transition patients carefully from one medication to another

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Partial agonists typically produce less receptor desensitization and internalization than full agonists because they generate a less intense signaling response that triggers weaker recruitment of beta-arrestins and GRK-mediated receptor phosphorylation

10.1038/sj.ijo.0803284 67 MathesC