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As GPX4 serves as the master regulator of lipid hydroperoxide reduction, its suppression triggers irreversible lipid peroxide accumulation that culminates in ferroptotic cell death (67, 68)
This means we must obtain it through diet or supplementation
This route also typically comes with even less medical oversight
The high levels of PtdIns-4-P then induce the recruitment of oxysterol-binding protein (OSBP)-related proteins (ORP) which in concert serve to stimulate new membrane contacts with the endoplasmic reticulum, ER
His comment gained widespread attention, though the humor of it was lost in his straight-faced delivery of it
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