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As a result of dysfunctional Wfs1 protein, all the main symptoms found in human were present in the Wfs1 transgenic rat, including endoplasmatic reticulum (ER) stress in the medulla, increased extraparenchymal space (EPS) around the medulla, and decreased medullary volume, with the largest decreases at the level of the inferior olive 6
Bull World Health Organ 46(3):337 Birnberg L, Climent-Sanz E, Codoer FM, Busquets N (2021) Microbiota variation across life stages of european field-caught Anopheles atroparvus and during laboratory colonization: new insights for malaria research
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